Myoglobin (clinical analyzes)

Content

Introduction

Myoglobin is a globular protein, located in the fibers of the muscles, which has the task of capturing the oxygen introduced into the body by breathing, storing it and transmitting it to the cells to allow the production of energy. Compared to hemoglobin, it carries less oxygen.

Normally, the doctor prescribes the myoglobin test (test) when he suspects that damage to the heart may have occurred. The myoglobin measurement, in fact, is performed together with that of two other substances, troponin and creatine kinase MB (CK- MB), which are specific markers of heart injury.

When the heart suffers from poor oxygen supply, myoglobin is very rapidly released into the plasma and is subsequently excreted in the urine. In the "span of two or three hours from the moment in which a heart attack or other muscle damage occurred, its values ​​tend to increase reaching a peak after about ten hours and then decrease, and return to normal levels, by twenty four hours.

A high amount of myoglobin in the blood, caused by severe muscle trauma, can cause acute kidney failure because at high concentrations it can be toxic to the body and damage the kidneys.

The test

The myoglobin test is a very simple test, has no contraindications and consists in taking a small amount (sample) of blood from a vein in the arm to check the amount of myoglobin present.

It is not necessary to be fasting even if, often, the analysis laboratories require it.After the blood collection, you can immediately return to normal activities.

Results

Normal blood myoglobin values ​​are between 0 and 85 nanograms / milliliter (ng / ml) but may vary depending on the technique used by the testing laboratories.

The test results can be influenced by certain physiological conditions such as age, sex, muscle mass.

Myoglobin can also be measured in urine where, to be normal, the maximum level must not exceed 4 milligrams / liter (4mg / L).

High levels of myoglobin in the blood can be associated with:

  • heart attack
  • muscle trauma
  • excessive physical activity
  • myositis
  • muscular dystrophy
  • chemical poisoning
  • drug intoxication
  • kidney failure
  • genetic predisposition

Low blood myoglobin values ​​can be caused by:

  • immune system problems
  • myasthenia gravis

The results of the analyzes must always be evaluated and interpreted by the attending physician who, should they prove to be higher or lower than the norm, will investigate the reasons.

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